President Trump’s review of federal research funding for major U.S. universities has sparked fierce opposition, prompting concerns about academic freedom and future scientific progress. The review has placed billions in research grants at risk for institutions like Columbia University ($400 million) and Harvard ($2.2 billion). This unprecedented move is generating significant uncertainty across the higher education landscape. 200 college presidents have voiced their concern over potential loss of academic independence, impacting vital research initiatives and innovation. The review’s effects could be felt across various fields including blockchain technology and healthcare, with consequences for both established institutions and emerging disciplines.